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What's a "difference" to you? If you want a great toned body, then expect to work-out for 6 months to 2 years before getting that "great bod" (all depends on your starting condition). If you've been eating right (1500-2000 calories a day, maximum, with plenty of water and healthy foods) and exercising for at least 30 minutes 3x a week, then my guess is that within a week or two, you should see some difference in your weight.
Without a lot of specifics, it's hard to say. How much weight do you need to lose? What is your BMI? That will give you a guideline as to how overweight you are. In order to have a great body, like doc said, it will take a while. To maintain a great body takes a lifetime. What is your level of commitment?